✉news ScienceBiology first seen 15 h ago, last 55 min ago, peak #18
p53 shown to prevent chromothripsis by balancing transcription and replication
Original: p53 keeps a transcription–replication balance that prevents chromothripsis
Research published in Nature reports that the p53 tumour suppressor protein maintains a balance between transcription and DNA replication, and that this balance prevents chromothripsis, a catastrophic form of chromosome shattering linked to cancer. The finding adds to understanding of how p53 suppresses tumours beyond its established roles in cell-cycle control and apoptosis, and highlights genome instability mechanisms relevant to cancer research.
Why now: A new Nature study reveals a previously unclear protective mechanism of a key tumour suppressor, drawing attention from the cancer research community.
Evidence
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