✉news SciencePhysics first seen 7 h ago, last 3 h ago, peak #25
Silicon effect enables new route for chiral alcohol couplings
Original: β-Silicon effect enables direct HAT for enantioconvergent couplings of α-silyl alcohols [IMAGE]
Chemists report that the beta-silicon effect enables direct hydrogen atom transfer (HAT) for enantioconvergent couplings of alpha-silyl alcohols. The finding means two different alcohol-derived fragments can be joined efficiently into a single enantioenriched product, a long-standing challenge in synthesis, with the silicon atom steering the reaction pathway. Researchers say the approach could simplify how complex chiral molecules, including potential drug candidates, are built from readily available alcohol starting materials.
Why now: A new synthetic chemistry method for building chiral molecules from alcohols is of broad interest to pharmaceutical and academic researchers.
alpha-silyl alcoholshydrogen atom transferbeta-silicon effect
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Evidence
- β-Silicon effect enables direct HAT for enantioconvergent couplings of α-silyl alcohols [IMAGE] · EurekAlert! Science News Releases
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